Yengil kremItki mikroloza (masalan, ekologik}} 242.27. likadagi kimyoviy formulasi tomonidan ishlab chiqarilgan o'simlikning estrogenik birikmasi - bu qattiq og'riqli sintezni talab qiladi va antijitik vositalar, antibiotiklar kabi omillar ta'sir qiladi. {{3} yoshi qo'zg'olonni kuchaytiradi va ko'k retseptorga bog'lab qo'yilgan (-7 hujayralari) {-7 hujayralarini skelet zichligi va issiq yonishi uchun skelet va yurak tarqalishiga olib kelishi mumkin. Aynan postmenopaulyal ayollar . Bir vaqtning o'zida NRF2 / C klinik sinovlari va II klinik tadrijiy bo'lib, II klinik tadrijiy bo'lib, uning ichaklarida -50 Mikrobiota {{13} ishlab chiqaruvchilardan 40% {{12} {{12} {{12} {{12} {{12} {{12} {{16} {{16} {vaginal quruqlik, tanadagi gormon darajasini muvozanatlash va kamaytirish bilan alomatlarni yaxshilaydi va Siydik va reproduktiv stol atrofiyasining estrogen etishmovchiligi tufayli yuzaga kelgan .
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Mahsulot nomi |
Yengil krem |
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Mahsulot turi |
Gumbaz |
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Mahsulotlar tozasi |
1g/10g |
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Mahsulot shakli |
Tashqi dastur |
Yengil krem Koa
Yadroli faol moddasiYengil kremIstronon (teng), ichak mikrobiota (masalan, saidestyin) metabolizatsiyasini (masalan, daddzein) metabolizatsiya qilish va noyob stereoizomerizmga ega bo'lgan. form, while R-Equol is inactive. The metabolic process of estradiol relies on a strict anaerobic environment and is significantly influenced by factors such as host dietary structure (such as soybean intake), antibiotic use, and age. Only 30% -50% of individuals in the Asian population have the ability to continuously produce Equol, which is Gut mikrobiota tarkibi bilan chambarchas bog'liq - ishlab chiqaruvchilarning ichakda etakchi bo'lmaganlar uchun lattajeli va bifidobakteriyalarning ko'pligi - ishlab chiqaruvchilarning 40% -60% pastroq.
Menopauza alteptomining relefi: estrogen retseptorni tartibga solish
Issiq yonishning asosiy mexanizmi . Ipotalamik neyronlarda (Rostralangan medullada joylashgan) ni tanlab olish va 126 ayolni boshqarish bo'yicha Clutramed Neyvulyatsiyani (RCT) qayta ishlash punkti uchun ortiqcha faollikni faollashtirishni o'z ichiga oladi 1% arizasi buni ko'rsatdiYengil kremKuniga ikki marta o'rtacha kuniga 4,9 martadan 4,9 martadan kuniga 2 martagacha (P<0.001), with a relative reduction of 62.8% from baseline. Its efficacy was better than that of the placebo group (28.5% reduction). Equol promotes osteoblast differentiation through the PI3K/Akt pathway while inhibiting RANKL mediated osteoclast formation. Clinical data shows that supplementing 10mg/day of Equol for one consecutive year can reduce the level of bone resorption marker urinary deoxypyridinoline by 23.94% and slow down the rate of bone density decline by 40%. For women with a high baseline risk of bone resorption, the level of urinary N-terminal peptide significantly decreased after Equol intervention (p=0.012), suggesting that they may prevent osteoporosis by regulating bone metabolism balance.
Tuyg'ular va bilimlarni mahalliy atrofitiy va nevroprotatsiyani boshqarish
Postmenopaulyalsdagi vaginal atrofiyasining kasalligi 50% ni tashkil qiladi, asosan epitelial yupqalashgan, ammo vaginal epitelial hujayralardagi (masalan, latin) va laminin {laminin {laminin) ning (laminin) va {lamin 2-sonli} ning ortib borayotganligini oshiradi. vaginal shilliq qavatining qalinligi shuni ko'rsatdiki, 8 haftalik aralashuvdan so'ng, shilliq qavatining qalinligi 0,32 mm, p {=0.004}}}}}}}}}}}}}}}}}}} 4,1 ball, p<0.001). Animal experiments have shown that Equol can reduce cocaine addiction behavior in HIV-1 related neurocognitive impairment rats, and its mechanism involves ER β - mediated activation of the PI3K/Akt pathway, reducing hippocampal neuronal apoptosis. In addition, Equol upregulates the expression of antioxidant enzymes (SOD2, TXNRD1) through the Nrf2/ARE pathway, reduces β - amyloid induced oxidative stress, and may have a preventive effect on neurodegenerative diseases such as Alzheimer's disease
Ekstrogenni ko'krak bezi to'qimalarida stimulyatsiya qilish uchun ekstrogni buzadi va ko'krak bezi saratoni xavfini kamaytiradi va ko'krak bezi saratoni xavfini kamaytiradi, bu giperplaziyani (qalinlik o'zgaradi).<0.5mm). Epidemiological studies further support this conclusion - the incidence rate of breast cancer in Equol producers is 27% lower than that in non producers (Japanese cohort study, n=12000). Although animal experiments suggest that long-term high-dose (>Soatiga 50mg / kg) T4 darajasini 18 foizga kamaytirishi mumkin, chunki u ketma-ket 30 mg dan 30 mg ga teng bo'lgan, . og'zaki ravishda og'zaki dispilatsiyani kamaytirishi mumkin emas Yengillik engil shishishiga olib kelishi mumkin (qariyb 8% ga teng), bu muammoni hal qilishda davom etadigan ikkita ko'zli platsebo tomonidan o'tkazilgan ikkita ko'rilg'i platsivli sinovlar (n =101 ni ko'rsatdi)Yengil kremSog'lom ko'ngillilarda juda jiddiy holatlar bilan yaxshi muloqot qilindi, ammo engil mahalliy eritemani ko'rsatilmagan holda (24 soat ichida hanuzgacha hal qilingan) . {}} {}}
Teri salomatligi: antioksidant va to'siqlarni ta'mirlash
BEPUL Radikalsni bevosita buzadigan: C vitaminiga qaraganda kuchli antioksidant kuchi
Poltifenololik birikma sifatida, tengol gidroksil guruhi sifatida uning molekulyar tuzumlari (O ₂⁻) kabi, masalan, reaktiv kislorodli turlarni (myro}}}, masalan, reaktiv kislorodli turlarni (myro}} {k) . {iccy in vitrogen atomlarini (IC) ajratish qobiliyati sezilarli darajada yaxshiroq (IC) ₅₀ =12 m. m) m (=25 =18} mk m m) va uning antioksidantasining kaoksilsining ulcistin ({4}} kaoksilesi, 10 m m oz mekni qisqartirish bilan taqqoslanadi ichidagi yournavers 58% ga, hujayralarning omon qolish darajasi 42% .
NRF2 / yo'lni faollashtirish: yo'l: enzogen antioksidant ferment ifodasini kuchaytirish
NRF2 (E2 bilan bog'liq bog'liq omillar 2) hujayrali antioksidantni mudofaa bo'yicha . . . . . complecten Corecial Tregchinor omilidir, NRF2 Kaap1-ga bog'lanadi va ubonkiitinatsiya bilan bog'liq; Oksidativ stress sharoitida NRF2 Kap1 dan ajratilgan, antioksidantga qarshi kurash elementlariga (masalan, SOD2, TXNRD1, yo {-1}) {{{-1} "}"} "}"} Tuzol "Quyidagi mexanizm orqali" Yillar "ni hisobga oladi:
Er-qaramlik aktivlashtirish: S-SES YOBUT / SSFORLES-ni PI3K / AKT signalini o'zgartirish, uning yadroviy tarjima qilishni targ'ib qilish;
Insonni to'g'ridan-to'g'ri KAP1-ga bog'lash: "SOD2, TXNRD1" ning kisteinatsiyasini blokirovka qilib, "SOD2, TXNRD1" va "MRNA" ning kistemasışırınıntığıni bog'lab, INS2, txnrd1 va ho -1 ning mrna ifoda darajasini pasaytirishi mumkinligini ko'rsatdi. 3.2- 2.8- kattila, 4.1- kamarning oksidlanishiga chidamliligini sezilarli darajada oshiradi .
Matritsa metalloprotreinasinazlarini (mmps) inhibeciancione (MMPS): Kollagen va Elastinni himoya qilish
Ultrabinafsha nurlanish va havo ifloslanishi (Kollagenase), MMP -9 -12 -12} ning tanazzulga olib keladi, terini yumshatish va ajinlar shakllanishiga olib keladi quyidagi yo'llar orqali mmf ifodasini inhibe qiladi: AP -1 Bloking Faoliyat mavjud: AP -1}}} ning DNKning tarqalishi va DNKning tarqalishi, shu bilan DNKning tarqalishi, shu bilan MMESni tranzit qilish; pastga tushirish; of TGF - 1/Smad pathway: Equol can inhibit TGF - 1-induced Smad2/3 phosphorylation and reduce the expression of MMP-1 and MMP-9.In a UV induced mouse skin photoaging model, local application of 1%Yengil kremMMP {{0} {{{1} {{1} {{1} {{1} {{1} {{1} {{1} {{1} {Elastin tarkibini 29% ga kamaytirdi.
Corneum strateum terining to'sig'ining asosiy tuzilishi va uning gidretationining asosiy tuzilishi - bu .} Yustol Corneum namligini kuchaytiradi:
Tabiiy namlovchi omilning sintezini (NMF) targ'ib qilish: Yengol "NMF" ni avlod avlodi (masalan, pirrolidon karboksil kislotasi, karbamid) ni qo'llab-quvvatlaydigan serinka ramzli inhibitor (spink5) va lorikinning ifodasini uyg'otadi;
Yikeduoyin bilan sinergik ta'sir: Yikeduoyin - bu "gidratatsiya qobig'i" ni himoya qilish uchun "gidratatsiya qobig'i" ni 52% ni tashkil qilishi mumkin bo'lgan "Gidratatsiya qobig'i" ni 41 foizga kamaytirishi mumkin, bu esa faqat ekidonni ishlatishdan ko'ra ancha yaxshi (ko'payib boradi). Namlik tarkibi 38% ga va rewlni qisqartirish 29% .
Qattiq aloqa protein ifodasini targ'ib qilish: Jismoniy to'siqlarni ta'mirlash
To'liq kesishqoq (TJ) keratinotsitlar va oqsillarning muhim qismidir (masalan, Klaudin -1}}} va Sudolin (masalan, klaudin -1} evro tengligi (masalan, Klaudin-1 YuNOL) quyidagi yo'llar orqali "TJ protein" iborasini keltirib chiqaradi:
EGFRE / Erk yo'lini yoqish: EGDRIN va ERK1 / 2 fosforiltsiyasi orqali Klaudin -1 -1 -1 -1 yoki okkrodinning ifodasini uyg'otadi;
NF-ni inhibe qilish - κ B yo'l-yo'riqchiligini yo'q qilish, men IL {{2} {{3} kabi yallig'lanish omillari va tnf {{} kabi yallig'lanish omillarini kamaytirishi mumkin
Keratinotsitlar monolayer modelida 10 m m2.3- 2.3- . . . 1.8- {{}} {{}} 1.8- {{}} 1.8- 1.8- 1.8- {{}} {{}} {1.8- bir vaqtning o'zida 45% ga oshdi, bu 45% ga oshdi. To'siq funktsiyasi .
Issiq teglar: Yetarli krem, etkazib beruvchilar, ishlab chiqaruvchilar, zavod, ulgurji, sotib olish, narx, asosiy, sotuv uchun