In recent years, as a hot-selling product for beauty, high-quality hyaluronic acid for skin has been enthusiastically sought after by people. Natural hyaluronic acid is a biodegradable and widely used macromolecular acid mucopolysaccharide. However, in fact, it is not uncommon, it is naturally formed and can be found in many organisms. In addition to the cosmetics industry, the role of hyaluronic acid for joints in orthopedic medicine cannot be ignored.
Here is the content list:
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Where does hyaluronic acid exist in the human body?
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How does hyaluronic acid treat inflammation of bone joints?
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What is the development prospect of hyaluronic acid's new dosage form?
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Where does hyaluronic acid exist in the human body?
Hyaluronic acid is a component shared by almost all mammalian cells, and it is widely present in connective tissue, epithelium, and nerve tissue. Hyaluronic acid is also an important component of most body fluids, such as synovial fluid, hyaline cartilage, synovial fluid of connective tissue, and vitreous of the eye.
Hyaluronic acid is an anion that can be combined with water molecules and has a strong water absorption capacity. It has physical properties similar to gelatin, such as hardness, viscosity, and lubrication.
Hyaluronic acid can enhance cell migration and proliferation, and as a component of extracellular matrix rich in carboxyl groups, it also has good biocompatibility and low immunogenicity.
The unique physical and chemical properties and biological properties of hyaluronic acid can be used in many fields of medicine, including tissue engineering, auxiliary ophthalmic surgery, and wound regeneration.
In addition, studies have shown that hyaluronic acid can be administered to the nasal cavity, oral cavity, lungs, eyes, and gastrointestinal trachea through different routes of administration, thereby acting on local lesions in the human body.
How does hyaluronic acid treat inflammation of bone joints?
Hyaluronic acid can induce the production of fibroblasts, keratinocytes, and pro-inflammatory cytokines, relieve osteoblasts' inflammation, and stimulate the synthesis of vascular endothelial cells.
Therefore, hyaluronic acid can promote the regeneration, chemotaxis, proliferation, and differentiation of bone mesenchymal cells, and play a therapeutic role in joint inflammation.
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Physical effect
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Due to its macromolecular network structure, the hyaluronic acid solution can have both the elasticity of the gel and the viscosity of the solution. This physical function plays an important role in the joint.
When walking, the inter-joint synovial fluid containing hyaluronic acid is a viscous solution, which can reduce friction between tissues. When running, the synovial fluid is an elastic solution, which can buffer the impact of stress on the joints.
Hyaluronic acid can reduce the pressure on the joints, protect the articular cartilage and the receptors on the cell and cell membrane, and maintain the integrity of the bone matrix.
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Pharmacological effect
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Supplementing exogenous hyaluronic acid can restore the synovial fluid in the pathological state to a normal state and interrupt the vicious circle.
Studies have shown that hyaluronic acid can scavenge free radicals, regulate leukocyte chemotaxis and macrophage phagocytosis, inhibit inflammation, inhibit the proliferation of blood vessels and tissues, and significantly relieve symptoms.
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Combined effect
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At present, in the clinical treatment of osteoarthritis, hyaluronic acid has gradually changed from a single drug to a combined application with other drugs or treatment methods. At the same time, in recent years, studies have also been done to create new dosage forms by changing the structure of hyaluronic acid in order to improve its therapeutic effects.
What is the development prospect of hyaluronic acid's new dosage form?
In the application of bone defect repair, a series of toxic and side effects produced by the cross-linking reaction of hyaluronic acid has become the limiting factor in the application of hyaluronic acid. At the same time, its application in bone tissue engineering is still limited to the repair of partial inflammation and small defects.
However, the application of hyaluronic acid in knee osteoarthritis can effectively reduce the cost of analgesics, NSAIDs, and other drugs, and increase the risk-benefit ratio.
In view of the limitation of single drug effects, combined drugs, and new dosage forms both show better therapeutic effects. Therefore, the combined application and other drugs, changes in which structure and biochemical properties to create new hyaluronic acid dosage forms with more accurate curative effects have a potential value of research.
Hyaluronic acid for topical medicine has unique physical and chemical properties and biological characteristics. Shaanxi BLOOM TECH Co., Ltd. believes that with the continuous deepening of scientific research and the continuous development of guided bone regeneration technology, medical hyaluronic acid will add far-reaching significance to the medical field. If you want to buy high-quality hyaluronic, please contact us.